Regioselective synthesis of 2,3′-biindoles mediated by an NBS-induced homo-coupling of indoles

Mild conditions have been developed to achieve NBS-induced homodimerization of indole derivatives with excellent regioselectivity at 15 °C in high efficiency. This method provides a simple route to a 2,3′-linked biindolyl scaffold from the electron-rich to moderately electron-poor indoles. In additi...

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Published in:Organic & biomolecular chemistry 2017, Vol.15 (45), p.9622-9629
Main Authors: Huang, Panpan, Peng, Xiangjun, Hu, Dan, Liao, Huiwu, Tang, Shaobin, Liu, Liangxian
Format: Article
Language:English
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Carbazole
Derivatives
Indoles
Regioselectivity
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cited_by cdi_FETCH-LOGICAL-c403t-35cfb3a549c2bd30697d9fc96bffac952bb021918d4039eab02cfada190c1ae83
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container_issue 45
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container_title Organic & biomolecular chemistry
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creator Huang, Panpan
Peng, Xiangjun
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description Mild conditions have been developed to achieve NBS-induced homodimerization of indole derivatives with excellent regioselectivity at 15 °C in high efficiency. This method provides a simple route to a 2,3′-linked biindolyl scaffold from the electron-rich to moderately electron-poor indoles. In addition, [3,2- a ]carbazole derivatives can also be prepared through this method. An efficient method for the synthesis of 2,3′-biindole and [3,2- a ]carbazole derivatives via an NBS-induced homo-coupling of indoles with high regioselectivity.
doi_str_mv 10.1039/c7ob02312j
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subjects Carbazole
Derivatives
Indoles
Regioselectivity
title Regioselective synthesis of 2,3′-biindoles mediated by an NBS-induced homo-coupling of indoles
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