Mercury-associated diagnoses among children diagnosed with pervasive development disorders

Nelson and Bauman (Pediatrics 111:674–679, 2003 ) previously hypothesized that pervasive developmental disorder (PDD) was not associated with mercury (Hg) exposure because the medical conditions associated with Hg exposure were not associated with PDD. A hypothesis-testing longitudinal case-control...

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Bibliographic Details
Published in:Metabolic brain disease 2018-06, Vol.33 (3), p.949-960
Main Authors: Geier, David A., Kern, Janet K., Sykes, Lisa K., Geier, Mark R.
Format: Article
Language:English
Subjects:
Biochemistry
Biological effects
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cerebral palsy
Child
Child Development Disorders, Pervasive - complications
Child Development Disorders, Pervasive - diagnosis
Child Development Disorders, Pervasive - etiology
Child, Preschool
Children
Contact dermatitis
Dermatitis
Developmental disabilities
Diagnosis
Eczema
Epilepsy
Exposure
Female
Humans
Hypotheses
Infant
Infant, Newborn
Longitudinal Studies
Male
Medical records
Mercury
Mercury (metal)
Mercury - toxicity
Metabolic Diseases
Neurology
Neurosciences
Oncology
Original Article
Paralysis
Pediatrics
Poisoning
Retrospective Studies
Sex Factors
Skin diseases
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Summary:Nelson and Bauman (Pediatrics 111:674–679, 2003 ) previously hypothesized that pervasive developmental disorder (PDD) was not associated with mercury (Hg) exposure because the medical conditions associated with Hg exposure were not associated with PDD. A hypothesis-testing longitudinal case-control study evaluated the frequency of medically diagnosed conditions previously associated with Hg poisoning, including: epilepsy, dysarthria, failure to thrive, cerebral palsy, or contact dermatitis and other eczema among children preceding their eventual PDD diagnosis (cases) compared to controls. A retrospective examination of medical records within the Vaccine Safety Datalink (VSD) was undertaken. Cases diagnosed with PDD ( n  = 534) were born from 1991 to 2000 and continuously enrolled until their PDD diagnosis. Controls ( n  = 26,367) were born from 1991 to 1993 and continuously enrolled from birth for 7.22 years. Within the first 5 years of life, cases compared to controls were significantly ( p  
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-018-0211-9