Clinical and Psychological Predictors of Switching from Active Surveillance to Active Treatment among Men with Low-Risk Prostate Cancer: the PREPARE Prospective Cohort Study

• Published in: Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2018-03, Vol.27 (3), p.357-358
• Main Authors: Taylor, KL, Luta, G, Zotou, V, Hoffman, RM, Lobo, T, Davis, KM, Potosky, AL, Aaronson, D, Van Den, Eeden S
• Format: Article
• Language: English
• Subjects: Anxiety; Biopsy; Cohort analysis; Cores; Decision making; Diagnosis; Health risks; Prostate cancer; Risk assessment; Surveillance
• ISSN: 1055-9965; 1538-7755
• DOI: 10.1158/1055-9965.EPI-18-0064

Numerous observational studies have assessed the clinical predictors of switching from active surveillance (AS) to active treatment (AT), but few have assessed psychological and decisional predictors. In a prospective, comparative effectiveness cohort study of men newly diagnosed with low-risk PCa, we assessed whether psychological and decisional factors predicted switching to AT after adjusting for clinical factors. We conducted pre-treatment telephone interviews (N = 1,139; 69.3% participation) with low-risk PCa patients (PSA < 10, Gleason < 7) and a follow-up assessment 6–10 months post-diagnosis (N = 1057; 93%). Clinical variables were obtained from the medical record. The current analysis included men who were on AS for up to 24 months (N = 515), compared to men on AS for >12 months who switched to AT between 12–24 months (N = 86). In Cox proportional hazard models, we included 2 time-dependent covariates measured between diagnosis and 24-months post-diagnosis: PSA (