The murine mutation jaundiced is caused by replacement of an arginine with a stop codon in the mRNA encoding the ninth repeat of (beta)-spectrin

Use of the normal nucleotide sequence to generate oligonucleotides for the polymerase chain reaction (PCR) amplification of mutant mRNA in the jaundiced mouse is discussed. Data indicate that point mutation is responsible for the severe reductions in beta-spectrin mRNA of jaundiced mice.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-10, Vol.91 (21), p.10099
Main Authors: Bloom, Michael L, Kaysser, Tamma M, Birkenmeier, Connie S, Barker, Jane E
Format: Article
Language:English
Subjects:
Medical research
Mutation
Ribonucleic acid
RNA
Rodents
Online Access:Get full text
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Description
Summary:Use of the normal nucleotide sequence to generate oligonucleotides for the polymerase chain reaction (PCR) amplification of mutant mRNA in the jaundiced mouse is discussed. Data indicate that point mutation is responsible for the severe reductions in beta-spectrin mRNA of jaundiced mice.
ISSN:0027-8424
1091-6490