The murine mutation jaundiced is caused by replacement of an arginine with a stop codon in the mRNA encoding the ninth repeat of (beta)-spectrin

Use of the normal nucleotide sequence to generate oligonucleotides for the polymerase chain reaction (PCR) amplification of mutant mRNA in the jaundiced mouse is discussed. Data indicate that point mutation is responsible for the severe reductions in beta-spectrin mRNA of jaundiced mice.

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Published in:Proceedings of the National Academy of Sciences - PNAS 1994-10, Vol.91 (21), p.10099
Main Authors: Bloom, Michael L, Kaysser, Tamma M, Birkenmeier, Connie S, Barker, Jane E
Format: Article
Language:English
Subjects:
Medical research
Mutation
Ribonucleic acid
RNA
Rodents
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container_title Proceedings of the National Academy of Sciences - PNAS
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creator Bloom, Michael L
Kaysser, Tamma M
Birkenmeier, Connie S
Barker, Jane E
description Use of the normal nucleotide sequence to generate oligonucleotides for the polymerase chain reaction (PCR) amplification of mutant mRNA in the jaundiced mouse is discussed. Data indicate that point mutation is responsible for the severe reductions in beta-spectrin mRNA of jaundiced mice.
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source Open Access: PubMed Central; JSTOR Archival Journals and Primary Sources Collection
subjects Medical research
Mutation
Ribonucleic acid
RNA
Rodents
title The murine mutation jaundiced is caused by replacement of an arginine with a stop codon in the mRNA encoding the ninth repeat of (beta)-spectrin
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