Direct evidence that G(i)-coupled receptor stimulation of mitogen-activated protein kinase is mediated to G(betagamma) activation of p21(ras)

Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein kinases (MAP kinases). Research results identify Gbetagamma as the primary mediator of Ras activation and subsequent signaling via MAP kinase in response to stimulation to Gi-coupled receptors.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-12, Vol.91 (26), p.12706
Main Authors: Koch, Walter J, Hawes, Brian E, Allen, Lee F, Lefkowitz, Robert J
Format: Article
Language:English
Subjects:
Cellular biology
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Description
Summary:Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein kinases (MAP kinases). Research results identify Gbetagamma as the primary mediator of Ras activation and subsequent signaling via MAP kinase in response to stimulation to Gi-coupled receptors.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.26.12706