Mechanism of GTP hydrolysis by G-protein (alpha) subunits

Hydrolysis of GTP by a variety of guanine nucleotide-binding proteins is a crucial step for regulation of these biological switches. A study used a conserved glutamic residue in the alpha subunit of G proteins to examine GTP hydrolysis.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-10, Vol.91 (21), p.9828
Main Authors: Kleuss, Christiane, Raw, Andre S, Lee, Ethan, Sprang, Stephen R, Gilman, Alfred G
Format: Article
Language:English
Subjects:
Biochemistry
Mutation
Proteins
Online Access:Get full text
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Description
Summary:Hydrolysis of GTP by a variety of guanine nucleotide-binding proteins is a crucial step for regulation of these biological switches. A study used a conserved glutamic residue in the alpha subunit of G proteins to examine GTP hydrolysis.
ISSN:0027-8424
1091-6490