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Role of the 75-kDa Tumor Necrosis Factor Receptor: Inhibition of Early Hematopoiesis
Biological effects of tumor necrosis factor α (TNF-α) are mediated through two cell surface receptors, the 55-kDa TNF receptor and the 75-kDa TNF receptor. The present study investigated the relative roles of the two TNF receptors in normal hematopoiesis. Using agonists (antibodies) specific for the...
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| Published in: | Proceedings of the National Academy of Sciences - PNAS 1994-10, Vol.91 (22), p.10695-10699 |
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| container_end_page | 10699 |
| container_issue | 22 |
| container_start_page | 10695 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 91 |
| creator | Jacobsen, Frede W. Rothe, Mike Rusten, Leiv Goeddel, David V. Smeland, Erlend B. Veiby, Ole P. Slordal, Lars Sen E. W. Jacobsen |
| description | Biological effects of tumor necrosis factor α (TNF-α) are mediated through two cell surface receptors, the 55-kDa TNF receptor and the 75-kDa TNF receptor. The present study investigated the relative roles of the two TNF receptors in normal hematopoiesis. Using agonists (antibodies) specific for the 55- and 75-kDa TNF receptors, we demonstrate differential roles of the two TNF receptors in hematopoiesis in that only the 55-kDa TNF receptor mediates antiproliferative effects of TNF-α on mature Lin-hematopoietic progenitor cells responding to granulocyte colony-stimulating factor or interleukin 3 alone. In contrast, the 75-kDa TNF receptor is essential in mediating inhibition of primitive Lin-Sca-1+high-proliferative-potential colony-forming cells and inhibition of the total number of proliferative clones of individually cultured Lin-Sca-1+Rh123loand Lin-Sca-1+Rh123hicells. |
| doi_str_mv | 10.1073/pnas.91.22.10695 |
| format | article |
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In contrast, the 75-kDa TNF receptor is essential in mediating inhibition of primitive Lin-Sca-1+high-proliferative-potential colony-forming cells and inhibition of the total number of proliferative clones of individually cultured Lin-Sca-1+Rh123loand Lin-Sca-1+Rh123hicells.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.91.22.10695</identifier><identifier>PMID: 7524102</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Agonists ; Animals ; Biochemistry ; Bone marrow ; Bone Marrow Cells ; Cell Differentiation - drug effects ; Cell Division - drug effects ; Cell growth ; Cells, Cultured ; Colony-Forming Units Assay ; Cytokines ; Granulocyte Colony-Stimulating Factor - pharmacology ; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology ; Hematopoiesis ; Hematopoiesis - drug effects ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - drug effects ; Hematopoietic Stem Cells - physiology ; Humans ; Immunity (Disease) ; Macrophage Colony-Stimulating Factor - pharmacology ; Macrophages ; Mice ; Mice, Inbred C57BL ; Molecular Weight ; Progenitor cells ; Radioligand Assay ; Receptors, Tumor Necrosis Factor - drug effects ; Receptors, Tumor Necrosis Factor - physiology ; Recombinant Proteins - pharmacology ; Tumor necrosis factor receptors ; Tumor Necrosis Factor-alpha - pharmacology ; Tumors</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1994-10, Vol.91 (22), p.10695-10699</ispartof><rights>Copyright 1994 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Oct 25, 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-a38a3d52530304618a38d2a571cabc1de96c9daac5daed3dfa44df029cdcef033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/91/22.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2366096$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2366096$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7524102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacobsen, Frede W.</creatorcontrib><creatorcontrib>Rothe, Mike</creatorcontrib><creatorcontrib>Rusten, Leiv</creatorcontrib><creatorcontrib>Goeddel, David V.</creatorcontrib><creatorcontrib>Smeland, Erlend B.</creatorcontrib><creatorcontrib>Veiby, Ole P.</creatorcontrib><creatorcontrib>Slordal, Lars</creatorcontrib><creatorcontrib>Sen E. W. Jacobsen</creatorcontrib><title>Role of the 75-kDa Tumor Necrosis Factor Receptor: Inhibition of Early Hematopoiesis</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Biological effects of tumor necrosis factor α (TNF-α) are mediated through two cell surface receptors, the 55-kDa TNF receptor and the 75-kDa TNF receptor. The present study investigated the relative roles of the two TNF receptors in normal hematopoiesis. Using agonists (antibodies) specific for the 55- and 75-kDa TNF receptors, we demonstrate differential roles of the two TNF receptors in hematopoiesis in that only the 55-kDa TNF receptor mediates antiproliferative effects of TNF-α on mature Lin-hematopoietic progenitor cells responding to granulocyte colony-stimulating factor or interleukin 3 alone. In contrast, the 75-kDa TNF receptor is essential in mediating inhibition of primitive Lin-Sca-1+high-proliferative-potential colony-forming cells and inhibition of the total number of proliferative clones of individually cultured Lin-Sca-1+Rh123loand Lin-Sca-1+Rh123hicells.</description><subject>Agonists</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Division - drug effects</subject><subject>Cell growth</subject><subject>Cells, Cultured</subject><subject>Colony-Forming Units Assay</subject><subject>Cytokines</subject><subject>Granulocyte Colony-Stimulating Factor - pharmacology</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology</subject><subject>Hematopoiesis</subject><subject>Hematopoiesis - drug effects</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Macrophage Colony-Stimulating Factor - pharmacology</subject><subject>Macrophages</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Weight</subject><subject>Progenitor cells</subject><subject>Radioligand Assay</subject><subject>Receptors, Tumor Necrosis Factor - drug effects</subject><subject>Receptors, Tumor Necrosis Factor - physiology</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Tumor necrosis factor receptors</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>Tumors</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNp9kc1v1DAQxS0EKkvhzgFExKHikmVsx06MuKDSL6kCqVrOltd2WC9JHGwH0f8ep7usWg6c7Jn3e6OxH0IvMSwx1PT9OKi4FHhJSK65YI_QAoPAJa8EPEYLAFKXTUWqp-hZjFsAEKyBI3RUM1JhIAu0uvGdLXxbpI0talb--KyK1dT7UHyxOvjoYnGudMr1jdV2zJcPxdWwcWuXnB9m45kK3W1xaXuV_OidzZbn6Emrumhf7M9j9O38bHV6WV5_vbg6_XRdasYhlYo2ihpGGAUKFce5agxRrMZarTU2VnAtjFKaGWUNNa2qKtMCEdpo2wKlx-jjbu44rXubm0MKqpNjcL0Kt9IrJx8qg9vI7_6XrBg0Tbaf7O3B_5xsTLJ3UduuU4P1U5SYc05pU2fw7T_g1k9hyE-TBDCpmWjmZWAHzd8Wg20Pe2CQc1hyDksKLAmRd2Fly-v7-x8M-3Sy_m6vz86_6r0Jsp26LtnfKaNv_o9m4tWO2Mac4gEhlHMQnP4BAlazKg</recordid><startdate>19941025</startdate><enddate>19941025</enddate><creator>Jacobsen, Frede W.</creator><creator>Rothe, Mike</creator><creator>Rusten, Leiv</creator><creator>Goeddel, David V.</creator><creator>Smeland, Erlend B.</creator><creator>Veiby, Ole P.</creator><creator>Slordal, Lars</creator><creator>Sen E. 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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1994-10, Vol.91 (22), p.10695-10699 |
| issn | 0027-8424 1091-6490 |
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| source | JSTOR Archival Journals and Primary Sources Collection; PubMed Central |
| subjects | Agonists Animals Biochemistry Bone marrow Bone Marrow Cells Cell Differentiation - drug effects Cell Division - drug effects Cell growth Cells, Cultured Colony-Forming Units Assay Cytokines Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Hematopoiesis Hematopoiesis - drug effects Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Humans Immunity (Disease) Macrophage Colony-Stimulating Factor - pharmacology Macrophages Mice Mice, Inbred C57BL Molecular Weight Progenitor cells Radioligand Assay Receptors, Tumor Necrosis Factor - drug effects Receptors, Tumor Necrosis Factor - physiology Recombinant Proteins - pharmacology Tumor necrosis factor receptors Tumor Necrosis Factor-alpha - pharmacology Tumors |
| title | Role of the 75-kDa Tumor Necrosis Factor Receptor: Inhibition of Early Hematopoiesis |
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