Purification of human leukotriene C(4) synthase

The purification to homogeneity of leukotriene (LT) C4 synthase and its identification as an 18-kDa protein, which suggests that it is a member of the family of microsomal glutathione S-transferases, are discussed. LTC4 synthase is the enzyme that catalyzes the conjugation of LTA4 with reduced gluta...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1992-12, Vol.89 (23), p.11603
Main Authors: Penrose, John F, Gagnon, Lyne, Myers, Paul, Lam, Bing K
Format: Article
Language:English
Subjects:
Biochemistry
Enzymes
Leukemia
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Summary:The purification to homogeneity of leukotriene (LT) C4 synthase and its identification as an 18-kDa protein, which suggests that it is a member of the family of microsomal glutathione S-transferases, are discussed. LTC4 synthase is the enzyme that catalyzes the conjugation of LTA4 with reduced glutathione to form LTC4.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.89.23.11603