Purification of human leukotriene C(4) synthase

The purification to homogeneity of leukotriene (LT) C4 synthase and its identification as an 18-kDa protein, which suggests that it is a member of the family of microsomal glutathione S-transferases, are discussed. LTC4 synthase is the enzyme that catalyzes the conjugation of LTA4 with reduced gluta...

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Published in:Proceedings of the National Academy of Sciences - PNAS 1992-12, Vol.89 (23), p.11603
Main Authors: Penrose, John F, Gagnon, Lyne, Myers, Paul, Lam, Bing K
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Language:English
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Biochemistry
Enzymes
Leukemia
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container_title Proceedings of the National Academy of Sciences - PNAS
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creator Penrose, John F
Gagnon, Lyne
Myers, Paul
Lam, Bing K
description The purification to homogeneity of leukotriene (LT) C4 synthase and its identification as an 18-kDa protein, which suggests that it is a member of the family of microsomal glutathione S-transferases, are discussed. LTC4 synthase is the enzyme that catalyzes the conjugation of LTA4 with reduced glutathione to form LTC4.
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source Open Access: PubMed Central; JSTOR Archival Journals and Primary Sources Collection
subjects Biochemistry
Enzymes
Leukemia
title Purification of human leukotriene C(4) synthase
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