U1 small nuclear RNA chimeric ribozymes with substrate specificty for the Rev pre-mRNA of human immunodeficiency virus

Michienzi et al have exploited the utilization of the U1 small nuclear RNA (snRNA) as a vector for specifically targeting a ribozyme into the nucleus. The resulting construct displays efficient cleavage activity in vitro.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1996-07, Vol.93 (14), p.7219
Main Authors: Michienzi, Alessandro, Prislei, Silvia, Bozzoni, Irene
Format: Article
Language:English
Subjects:
Medical research
Ribonucleic acid
RNA
Viruses
Online Access:Get full text
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Description
Summary:Michienzi et al have exploited the utilization of the U1 small nuclear RNA (snRNA) as a vector for specifically targeting a ribozyme into the nucleus. The resulting construct displays efficient cleavage activity in vitro.
ISSN:0027-8424
1091-6490