aPKC[lamda]/[iota] promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6

Understanding the mechanism by which hormone refractory prostate cancer (HRPC) develops remains a major issue. Alterations in HRPC include androgen receptor (AR) changes. In addition, the AR is activated by cytokines such as interleukin-6 (IL-6). Atypical protein kinase C (aPKC.../...) has been impl...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2009-09, Vol.106 (38), p.16369
Main Authors: Ishiguro, Hitoshi, Akimoto, Kazunori, Nagashima, Yoji, Kojima, Yasuyuki, Sasaki, Takeshi, Ishiguro-Imagawa, Yukari, Nakaigawa, Noboru, Ohno, Shigeo, Kubota, Yoshinobu, Uemura, Hiroji
Format: Article
Language:English
Subjects:
Biomarkers
Cell growth
Correlation analysis
Cytokines
Hormones
Kinases
Prostate cancer
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Understanding the mechanism by which hormone refractory prostate cancer (HRPC) develops remains a major issue. Alterations in HRPC include androgen receptor (AR) changes. In addition, the AR is activated by cytokines such as interleukin-6 (IL-6). Atypical protein kinase C (aPKC.../...) has been implicated in the progression of several cancers. Herein, we provide evidence that aPKC.../... expression correlates with prostate cancer recurrence. Experiments in vitro and in vivo revealed aPKC.../... to be involved in prostate cancer cell growth through secretion of IL-6. Further, aPKC.../... activates transcription of the IL-6 gene through NF...B and AP-1. We conclude that aPKC.../... promotes the growth of hormone independent prostate cancer cells by stimulating IL-6 production in an autocrine manner. Our findings not only explain the link between aPKC.../... and IL-6, implicated in the progression a variety of cancers, but also establish a molecular change involved in the development of HRPC. Further, aPKC.../... expression might be a biomarker for prostate cancer progression. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0027-8424
1091-6490