Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74 gives Val or Ile

The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydroquinoxaline-2(1H)-thione (HBY 097) is used to select for drug-resistant HIV-1 variants in vitro. Results suggest that there is a link between HIV-1 resistance against two types of co...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1996-01, Vol.93 (1), p.34
Main Authors: Kleim, Jorg-Peter, Rosner, Manfred, Winkler, Irvin, Paessens, Arno
Format: Article
Language:English
Subjects:
Biochemistry
Drugs
HIV
Human immunodeficiency virus
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Summary:The quinoxaline nonnucleoside RT inhibitor (NNRTI) (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-dihydroquinoxaline-2(1H)-thione (HBY 097) is used to select for drug-resistant HIV-1 variants in vitro. Results suggest that there is a link between HIV-1 resistance against two types of compounds, which inhibit the HIV-1 RT and virus replication through different modes.
ISSN:0027-8424
1091-6490