Secondary Absence of Mitochondria in Giardia lamblia and Trichomonas vaginalis Revealed by valyl-tRNA Synthetase Phylogeny

Nuclear-coded valyl-tRNA synthetase (ValRS) of eukaryotes is regarded of mitochondrial origin. Complete ValRS sequences obtained by us from two amitochondriate protists, the diplomonad, Giardia lamblia and the parabasalid, Trichomonas vaginalis were of the eukaryotic type, strongly suggesting an ide...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1998-06, Vol.95 (12), p.6860-6865
Main Authors: Hashimoto, Tetsuo, Sanchez, Lidya B., Shirakura, Tetsurou, Muller, Miklos, Hasegawa, Masami
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
Bacteria
Biological Sciences
Cloning, Molecular
DNA
Eukaryotic cells
Evolution
Fungi
Genes
Genomics
Giardia lamblia - genetics
Giardia lamblia - ultrastructure
Microorganisms
Mitochondria
Mitochondria - genetics
Molecular Sequence Data
Phylogeny
Proteins
Ribonucleic acid
RNA
Sequence Alignment
Topology
Trichomonas vaginalis - genetics
Trichomonas vaginalis - ultrastructure
Valine-tRNA Ligase - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nuclear-coded valyl-tRNA synthetase (ValRS) of eukaryotes is regarded of mitochondrial origin. Complete ValRS sequences obtained by us from two amitochondriate protists, the diplomonad, Giardia lamblia and the parabasalid, Trichomonas vaginalis were of the eukaryotic type, strongly suggesting an identical history of ValRS in all eukaryotes studied so far. The findings indicate that diplomonads are secondarily amitochondriate and give further evidence for such conclusion reached recently concerning parabasalids. Together with similar findings on other amitochondriate groups (microsporidia and entamoebids), this work provides critical support for the emerging notion that no representatives of the premitochondrial stage of eukaryotic phylogenesis exist among the species living today.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.95.12.6860