Gelsolin and ADF/Cofilin Enhance the Actin Dynamics of Motile Cells

In initial studies of the actin dynamics of motile cells, gelsolin was considered to be of primary importance in regulating the dynamic actin cytoskeletal changes associated with ameboid movement. However, more recent studies have led scientists to believe that actin depolymerizing factor (ADF)-cofi...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2000-06, Vol.97 (13), p.6936-6938
Main Author: Southwick, Frederick S.
Format: Article
Language:English
Subjects:
Actin Depolymerizing Factors
Actins
Actins - physiology
Animals
Calcium
Cell motility
Cell Movement
Cellular biology
Commentaries
Delta cells
Fibroblasts
Gelsolin - physiology
Humans
Listeria
Microfilament Proteins - physiology
Microfilaments
Microorganisms
Monomers
Platelets
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In initial studies of the actin dynamics of motile cells, gelsolin was considered to be of primary importance in regulating the dynamic actin cytoskeletal changes associated with ameboid movement. However, more recent studies have led scientists to believe that actin depolymerizing factor (ADF)-cofilin is primarily responsible for remodeling the actin cytoskeleton. To gain a more objective perspective on the contribution of these proteins to actin-filament dynamics, the experimental data derived from each of these approaches are analyzed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.97.13.6936