The nonpeptide WIN 64338 is a bradykinin B(2) receptor antagonist

The synthesis and in vitro biological activity of the nonpeptide bradykinin receptor antagonist WIN 64338 are discussed. Synthesis of WIN 64338 provides a nonpeptide competitive bradykinin B2 antagonist active in both bradykinin radioligand binding and functional assays.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-05, Vol.91 (11), p.4693
Main Authors: Sawutz, David G, Salvino, Joseph M, Dolle, Roland E, Casiano, Fran
Format: Article
Language:English
Subjects:
Biochemistry
Pharmacology
Online Access:Get full text
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Description
Summary:The synthesis and in vitro biological activity of the nonpeptide bradykinin receptor antagonist WIN 64338 are discussed. Synthesis of WIN 64338 provides a nonpeptide competitive bradykinin B2 antagonist active in both bradykinin radioligand binding and functional assays.
ISSN:0027-8424
1091-6490