Loading…
Crystal Structure of a Human TATA Box-Binding Protein/TATA Element Complex
The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovir...
Saved in:
| Published in: | Proceedings of the National Academy of Sciences - PNAS 1996-05, Vol.93 (10), p.4862-4867 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c584t-b0b8675bf8c63784e23e58bdc9183bed67757820f4785cb06ddb9c04742c5d673 |
|---|---|
| cites | |
| container_end_page | 4867 |
| container_issue | 10 |
| container_start_page | 4862 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 93 |
| creator | Nikolov, Dimitar B. Chen, Hua Halay, Elaine D. Hoffmann, Alexander Roeder, Robert G. Burley, Stephen K. |
| description | The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstrom resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9- angstrom -resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box. |
| doi_str_mv | 10.1073/pnas.93.10.4862 |
| format | article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_journals_201341989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>38867</jstor_id><sourcerecordid>38867</sourcerecordid><originalsourceid>FETCH-LOGICAL-c584t-b0b8675bf8c63784e23e58bdc9183bed67757820f4785cb06ddb9c04742c5d673</originalsourceid><addsrcrecordid>eNqFkc9v0zAcxS3ENMrgjIQEijjAKa1_xrbEpasGA00CiXK2HMcZqZy4sx3U_fc4a-kYBzhZX73P--p9_QB4geAcQU4W20HHuSR5mFNR4UdghqBEZUUlfAxmEGJeCorpE_A0xg2EUDIBT8GpqCihks7A51W4jUm74lsKo0ljsIVvC11cjr0eivVyvSzO_a4874amG66Lr8En2w2LO-HC2d4OqVj5fuvs7hk4abWL9vnhPQPfP1ysV5fl1ZePn1bLq9IwQVNZw1pUnNWtMBXhglpMLBN1YyQSpLZNxTnjAsOWcsFMDaumqaWBlFNsWFbJGXi_37sd6942JkcI2qlt6HodbpXXnXqoDN0Pde1_KiIJh9n-9mAP_ma0Mam-i8Y6pwfrx6i4gJhKif4LIsZyJswy-OYvcOPHMOQ_UBgiQpEUMkOLPWSCjzHY9hgYQTVVqaYqlSTTPFWZHa_-vPPIH7rL-ruDPhl_q_cLVDs6l-wuZfL1P8kMvNwDm5h8OBJE5KbIL1KYueo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201341989</pqid></control><display><type>article</type><title>Crystal Structure of a Human TATA Box-Binding Protein/TATA Element Complex</title><source>Open Access: PubMed Central</source><source>JSTOR-E-Journals</source><creator>Nikolov, Dimitar B. ; Chen, Hua ; Halay, Elaine D. ; Hoffmann, Alexander ; Roeder, Robert G. ; Burley, Stephen K.</creator><creatorcontrib>Nikolov, Dimitar B. ; Chen, Hua ; Halay, Elaine D. ; Hoffmann, Alexander ; Roeder, Robert G. ; Burley, Stephen K.</creatorcontrib><description>The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstrom resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9- angstrom -resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.93.10.4862</identifier><identifier>PMID: 8643494</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Amino acids ; Arabidopsis - chemistry ; Arabidopsis thaliana ; Atomic interactions ; Atoms ; Base Sequence ; Conserved Sequence ; Crystallography ; Crystallography, X-Ray ; DNA ; DNA - chemistry ; DNA - genetics ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Humans ; Hydrogen bonds ; Models, Molecular ; Molecular biology ; Molecular Sequence Data ; Molecular Structure ; Molecules ; Nucleic Acid Conformation ; Phosphates ; Plant Proteins - chemistry ; Protein Conformation ; Proteins ; TATA Box ; TATA-Box Binding Protein ; Transcription Factors - chemistry ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Yeasts</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (10), p.4862-4867</ispartof><rights>Copyright 1996 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences May 14, 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-b0b8675bf8c63784e23e58bdc9183bed67757820f4785cb06ddb9c04742c5d673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/93/10.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/38867$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/38867$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8643494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nikolov, Dimitar B.</creatorcontrib><creatorcontrib>Chen, Hua</creatorcontrib><creatorcontrib>Halay, Elaine D.</creatorcontrib><creatorcontrib>Hoffmann, Alexander</creatorcontrib><creatorcontrib>Roeder, Robert G.</creatorcontrib><creatorcontrib>Burley, Stephen K.</creatorcontrib><title>Crystal Structure of a Human TATA Box-Binding Protein/TATA Element Complex</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstrom resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9- angstrom -resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Arabidopsis - chemistry</subject><subject>Arabidopsis thaliana</subject><subject>Atomic interactions</subject><subject>Atoms</subject><subject>Base Sequence</subject><subject>Conserved Sequence</subject><subject>Crystallography</subject><subject>Crystallography, X-Ray</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>DNA - genetics</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>Hydrogen bonds</subject><subject>Models, Molecular</subject><subject>Molecular biology</subject><subject>Molecular Sequence Data</subject><subject>Molecular Structure</subject><subject>Molecules</subject><subject>Nucleic Acid Conformation</subject><subject>Phosphates</subject><subject>Plant Proteins - chemistry</subject><subject>Protein Conformation</subject><subject>Proteins</subject><subject>TATA Box</subject><subject>TATA-Box Binding Protein</subject><subject>Transcription Factors - chemistry</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Yeasts</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkc9v0zAcxS3ENMrgjIQEijjAKa1_xrbEpasGA00CiXK2HMcZqZy4sx3U_fc4a-kYBzhZX73P--p9_QB4geAcQU4W20HHuSR5mFNR4UdghqBEZUUlfAxmEGJeCorpE_A0xg2EUDIBT8GpqCihks7A51W4jUm74lsKo0ljsIVvC11cjr0eivVyvSzO_a4874amG66Lr8En2w2LO-HC2d4OqVj5fuvs7hk4abWL9vnhPQPfP1ysV5fl1ZePn1bLq9IwQVNZw1pUnNWtMBXhglpMLBN1YyQSpLZNxTnjAsOWcsFMDaumqaWBlFNsWFbJGXi_37sd6942JkcI2qlt6HodbpXXnXqoDN0Pde1_KiIJh9n-9mAP_ma0Mam-i8Y6pwfrx6i4gJhKif4LIsZyJswy-OYvcOPHMOQ_UBgiQpEUMkOLPWSCjzHY9hgYQTVVqaYqlSTTPFWZHa_-vPPIH7rL-ruDPhl_q_cLVDs6l-wuZfL1P8kMvNwDm5h8OBJE5KbIL1KYueo</recordid><startdate>19960514</startdate><enddate>19960514</enddate><creator>Nikolov, Dimitar B.</creator><creator>Chen, Hua</creator><creator>Halay, Elaine D.</creator><creator>Hoffmann, Alexander</creator><creator>Roeder, Robert G.</creator><creator>Burley, Stephen K.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960514</creationdate><title>Crystal Structure of a Human TATA Box-Binding Protein/TATA Element Complex</title><author>Nikolov, Dimitar B. ; Chen, Hua ; Halay, Elaine D. ; Hoffmann, Alexander ; Roeder, Robert G. ; Burley, Stephen K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-b0b8675bf8c63784e23e58bdc9183bed67757820f4785cb06ddb9c04742c5d673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Arabidopsis - chemistry</topic><topic>Arabidopsis thaliana</topic><topic>Atomic interactions</topic><topic>Atoms</topic><topic>Base Sequence</topic><topic>Conserved Sequence</topic><topic>Crystallography</topic><topic>Crystallography, X-Ray</topic><topic>DNA</topic><topic>DNA - chemistry</topic><topic>DNA - genetics</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>Hydrogen bonds</topic><topic>Models, Molecular</topic><topic>Molecular biology</topic><topic>Molecular Sequence Data</topic><topic>Molecular Structure</topic><topic>Molecules</topic><topic>Nucleic Acid Conformation</topic><topic>Phosphates</topic><topic>Plant Proteins - chemistry</topic><topic>Protein Conformation</topic><topic>Proteins</topic><topic>TATA Box</topic><topic>TATA-Box Binding Protein</topic><topic>Transcription Factors - chemistry</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikolov, Dimitar B.</creatorcontrib><creatorcontrib>Chen, Hua</creatorcontrib><creatorcontrib>Halay, Elaine D.</creatorcontrib><creatorcontrib>Hoffmann, Alexander</creatorcontrib><creatorcontrib>Roeder, Robert G.</creatorcontrib><creatorcontrib>Burley, Stephen K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikolov, Dimitar B.</au><au>Chen, Hua</au><au>Halay, Elaine D.</au><au>Hoffmann, Alexander</au><au>Roeder, Robert G.</au><au>Burley, Stephen K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crystal Structure of a Human TATA Box-Binding Protein/TATA Element Complex</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1996-05-14</date><risdate>1996</risdate><volume>93</volume><issue>10</issue><spage>4862</spage><epage>4867</epage><pages>4862-4867</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstrom resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9- angstrom -resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8643494</pmid><doi>10.1073/pnas.93.10.4862</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (10), p.4862-4867 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_journals_201341989 |
| source | Open Access: PubMed Central; JSTOR-E-Journals |
| subjects | Amino Acid Sequence Amino acids Arabidopsis - chemistry Arabidopsis thaliana Atomic interactions Atoms Base Sequence Conserved Sequence Crystallography Crystallography, X-Ray DNA DNA - chemistry DNA - genetics DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Hydrogen bonds Models, Molecular Molecular biology Molecular Sequence Data Molecular Structure Molecules Nucleic Acid Conformation Phosphates Plant Proteins - chemistry Protein Conformation Proteins TATA Box TATA-Box Binding Protein Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Yeasts |
| title | Crystal Structure of a Human TATA Box-Binding Protein/TATA Element Complex |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T06%3A24%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Crystal%20Structure%20of%20a%20Human%20TATA%20Box-Binding%20Protein/TATA%20Element%20Complex&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Nikolov,%20Dimitar%20B.&rft.date=1996-05-14&rft.volume=93&rft.issue=10&rft.spage=4862&rft.epage=4867&rft.pages=4862-4867&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.93.10.4862&rft_dat=%3Cjstor_proqu%3E38867%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c584t-b0b8675bf8c63784e23e58bdc9183bed67757820f4785cb06ddb9c04742c5d673%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=201341989&rft_id=info:pmid/8643494&rft_jstor_id=38867&rfr_iscdi=true |