Calcification in Atherosclerosis: Bone Biology and Chronic Inflammation at the Arterial Crossroads

Dystrophic or ectopic mineral deposition occurs in many pathologic conditions, including atherosclerosis. Calcium mineral deposits that frequently accompany atherosclerosis are readily quantifiable radiographically, serve as a surrogate marker for the disease, and predict a higher risk of myocardial...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2003-09, Vol.100 (20), p.11201-11206
Main Authors: Doherty, Terence M., Asotra, Kamlesh, Fitzpatrick, Lorraine A., Qiao, Jian-Hua, Wilkin, Douglas J., Detrano, Robert C., Dunstan, Colin R., Shah, Prediman K., Rajavashisth, Tripathi B.
Format: Article
Language:English
Subjects:
Animals
Arteries
Arteries - physiopathology
Atherosclerosis
Bone and Bones - physiopathology
Bone Development
Bone mineralization
Bones
Calcinosis
Calcium
Cardiovascular disease
Chondrocytes
Chronic Disease
Humans
Inflammation - physiopathology
Medical research
Mice
Minerals
Osteoclasts
Perspectives
Pulmonary arteries
Stem cells
Tomography, X-Ray Computed
Vascular calcification
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Summary:Dystrophic or ectopic mineral deposition occurs in many pathologic conditions, including atherosclerosis. Calcium mineral deposits that frequently accompany atherosclerosis are readily quantifiable radiographically, serve as a surrogate marker for the disease, and predict a higher risk of myocardial infarction and death. Accelerating research interest has been propelled by a clear need to understand how plaque structure, composition, and stability lead to devastating cardiovascular events. In atherosclerotic plaque, accumulating evidence is consistent with the notion that calcification involves the participation of arterial osteoblasts and osteoclasts. Here we summarize current models of intimal arterial plaque calcification and highlight intriguing questions that require further investigation. Because atherosclerosis is a chronic vascular inflammation, we propose that arterial plaque calcification is best conceptualized as a convergence of bone biology with vascular inflammatory pathobiology.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1932554100