Posttranslational modification of Galphao1 generates Galphao3, an abudant G protein in brain

Galphao, the most abundant G protein in mammalian brain, occurs at least in two subforms, i.e., Galphao1 and Galphao2, derived by alternative splicing of the mRNA. A third Galphao1-related isoform, Galphao3, has been purified, representing about 30% of total Go in brain.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-02, Vol.96 (4), p.1327
Main Authors: Exner, Torsten, Jensen, Ole N, Mann, Matthias, Kleuss, Christiane, Nurnberg, Bernd
Format: Article
Language:English
Subjects:
Biochemistry
Brain
Proteins
Online Access:Get full text
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Description
Summary:Galphao, the most abundant G protein in mammalian brain, occurs at least in two subforms, i.e., Galphao1 and Galphao2, derived by alternative splicing of the mRNA. A third Galphao1-related isoform, Galphao3, has been purified, representing about 30% of total Go in brain.
ISSN:0027-8424
1091-6490