Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase

This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragm...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2006-10, Vol.103 (43), p.15911-15915
Main Authors: Williams, K.D, Busto, M, Suster, M.L, So, A.K.C, Ben-Shahar, Y, Leevers, S.J, Sokolowski, M.B
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal
Biological Sciences
Biological variation
Caenorhabditis elegans
Diapause
Drosophila melanogaster
Drosophila melanogaster - enzymology
Drosophila melanogaster - genetics
Enzymes
Evolutionary genetics
gene deletion
gene dosage
Gene Dosage - genetics
Gene expression
Genes
Genetic variation
Genetic Variation - genetics
Genomics
Heterozygotes
Insect genetics
Insects
Insulin
Insulin - metabolism
Molecular Sequence Data
mutation
nervous system
Neurons
Neurons - metabolism
nucleotide sequences
Phenotype
Phenotypes
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
RNA
Sequence Analysis, DNA
Sequence Analysis, RNA
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Summary:This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. The roles of phosphatidylinositol 3-kinase for both diapause in D. melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0604592103