The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)positive RNA in the cytoplasm

The role of the yeast Ran/TC4 homologue in transport in and out of the nucleus was tested. Findings suggest that hydrolysis of GTP by Ran/TC4 is necessary for proper import of proteins into the nucleus and appearance of poly(A)positive RNA in the cytoplasm.

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1995-01, Vol.92 (1), p.225
Main Authors: Schlenstedt, Gabriel, Saavedra, Claudio, Loeb, Jonathan D J, Cole, Charles N, Silver, Pamela A
Format: Article
Language:English
Subjects:
Cellular biology
Proteins
Ribonucleic acid
RNA
Yeast
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The role of the yeast Ran/TC4 homologue in transport in and out of the nucleus was tested. Findings suggest that hydrolysis of GTP by Ran/TC4 is necessary for proper import of proteins into the nucleus and appearance of poly(A)positive RNA in the cytoplasm.
ISSN:0027-8424
1091-6490