Histone H2A-mediated transient cytokine gene delivery induced efficient antitumor responses in murine neuroblastoma

A major goal of cancer immunotherapy is the induction of a cell-mediated antitumor response in poorly immunogenic malignancies. We tested the hypothesis that this can be achieved by cytokine gene therapy with a novel histone H2A-based transient transfection procedure.

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2000-10, Vol.97 (21), p.11500
Main Authors: Balicki, Danuta, Reisfeld, Ralph A, Pertl, Ursula, Beutler, Ernest, Lode, Holger N
Format: Article
Language:English
Subjects:
Cytokines
Genes
Immunology
Medical research
Online Access:Get full text
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Summary:A major goal of cancer immunotherapy is the induction of a cell-mediated antitumor response in poorly immunogenic malignancies. We tested the hypothesis that this can be achieved by cytokine gene therapy with a novel histone H2A-based transient transfection procedure.
ISSN:0027-8424
1091-6490