Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain

The neural circuits that regulate sleep and arousal as well as their integration with circadian circuits remain unclear, especially in DROSOPHILA: This issue intersects with that of photoreception, because light is both an arousal signal in diurnal animals and an entraining signal for the circadian...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2008-12, Vol.105 (50), p.19587-19594
Main Authors: Shang, Yuhua, Griffith, Leslie C, Rosbash, Michael
Format: Article
Language:English
Subjects:
Animals
Arousal
Biological Sciences
Biology
Brain
Cells
Circadian Rhythm
Drosophila
Drosophila melanogaster
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Drosophila melanogaster - radiation effects
Drosophila Proteins - metabolism
Genotypes
Insects
large ventral lateral neurons
lateral neurons
Lateral Ventricles - cytology
Lateral Ventricles - physiology
Lateral Ventricles - radiation effects
Light
Locomotion
Mosaic
Nerve Net - cytology
Nerve Net - physiology
Nerve Net - radiation effects
Neural conduction
Neurons
neuropeptide PDF
neuropeptides
neurophysiology
Phenotypes
photoreception
Photoreceptor Cells, Invertebrate - cytology
Photoreceptor Cells, Invertebrate - physiology
Photoreceptor Cells, Invertebrate - radiation effects
Receptors, G-Protein-Coupled - metabolism
Sleep
Transgenes
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Summary:The neural circuits that regulate sleep and arousal as well as their integration with circadian circuits remain unclear, especially in DROSOPHILA: This issue intersects with that of photoreception, because light is both an arousal signal in diurnal animals and an entraining signal for the circadian clock. To identify neurons and circuits relevant to light-mediated arousal as well as circadian phase-shifting, we developed genetic techniques that link behavior to single cell-type resolution within the Drosophila central brain. We focused on the unknown function of the 10 PDF-containing large ventral lateral neurons (l-LNvs) of the Drosophila circadian brain network and show here that these cells function in light-dependent arousal. They also are important for phase shifting in the late-night (dawn), indicating that the circadian photoresponse is a network property and therefore non-cell-autonomous. The data further indicate that the circuits underlying light-induced arousal and circadian photoentrainment intersect at the l-LNvs and then segregate.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0809577105