Obesity and mild hyperinsulinema found in neuropeptide Y-Y1 receptor-deficient mice

To elucidate the role of neuropeptide Y (NPY)-Y1 receptor (Y1-R) in food intake, energy expenditure, and other possible functions, we have generated Y1-R-deficient mice (Y1-R-/-) by gene targeting. Contrary to our hypothesis that the lack of NPY signaling via Y1-R would result in impaired feeding an...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1998-12, Vol.95 (26), p.15659
Main Authors: Kushi, Atsuko, Sasai, Hitoshi, Koizumi, Haruko, Takeda, Noriko
Format: Article
Language:English
Subjects:
Insulin
Obesity
Peptides
Proteins
Rodents
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Summary:To elucidate the role of neuropeptide Y (NPY)-Y1 receptor (Y1-R) in food intake, energy expenditure, and other possible functions, we have generated Y1-R-deficient mice (Y1-R-/-) by gene targeting. Contrary to our hypothesis that the lack of NPY signaling via Y1-R would result in impaired feeding and weight loss, Y1-R-/- mice showed a moderate obesity and mild hyperinsulinemia without hyperphagia.
ISSN:0027-8424
1091-6490