Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-A(kappa)

A murine B-cell lymphoma bearing the class II major histocompatibility complex (MHC) molecule 1-Ak was cultured with the protein antigen hen egg white lysozyme (HEL). The results demonstrate that the HEL epitope containing residues 52-61 is the most abundant HEL epitope presented on the MHC of the a...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1992-08, Vol.89 (16), p.7380
Main Authors: Nelson, Christopher A, Roof, Richard W, McCourt, David W, Unanue, Emil R
Format: Article
Language:English
Subjects:
Immunity (Disease)
Medical research
Molecules
Proteins
Online Access:Get full text
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Summary:A murine B-cell lymphoma bearing the class II major histocompatibility complex (MHC) molecule 1-Ak was cultured with the protein antigen hen egg white lysozyme (HEL). The results demonstrate that the HEL epitope containing residues 52-61 is the most abundant HEL epitope presented on the MHC of the antigen-presenting cells.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.89.16.7380