Alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentviral-based model of Parkinson's disease

Parkinson's disease (PD) is characterized by the progressive loss of substantia nigra dopaminergic neurons and the presence of cytoplasmic inclusions named Lewy bodies. To develop an animal model of PD, lentiviral vectors expressing different human or rat forms of alpha-syn were injected into t...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-08, Vol.99 (16), p.10813
Main Authors: C Lo Bianco, J-L Ridet, Schneider, B L, Deglon, N, Aebischer, P
Format: Article
Language:English
Subjects:
Biology
Neurology
Neurons
Parkinson's disease
Rodents
Online Access:Get full text
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Summary:Parkinson's disease (PD) is characterized by the progressive loss of substantia nigra dopaminergic neurons and the presence of cytoplasmic inclusions named Lewy bodies. To develop an animal model of PD, lentiviral vectors expressing different human or rat forms of alpha-syn were injected into the substantia nigra of rats.
ISSN:0027-8424
1091-6490