Miniature endplate current rise times less than 100 mus from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle

Miniature endplate currents were recorded using simultaneous voltage clamp and extracellular methods, allowing correction for time course measurement errors. It was concluded that passive transmitter diffusion, coupled with rapid expansion of the fusion pore, is sufficient to explain the time course...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1996-06, Vol.93 (12), p.5747
Main Authors: Stiles, Joel R, Van Helden, Dirk, Bartol, Thomas M, Salpeter, Edwin E, Salpeter, Miriam M
Format: Article
Language:English
Subjects:
Cellular biology
Physics
Online Access:Get full text
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Summary:Miniature endplate currents were recorded using simultaneous voltage clamp and extracellular methods, allowing correction for time course measurement errors. It was concluded that passive transmitter diffusion, coupled with rapid expansion of the fusion pore, is sufficient to explain the time course of experimentally measured synaptic currents with trs of less than 100 mus.
ISSN:0027-8424
1091-6490