DOSE DEPENDENT EFFECT OF INTRAVENOUS FENTANYL ADMINISTRATION ON TICAGRELOR ABSORPTION AND PLATELET INHIBITION IN PATIENTS RECEIVING PERCUTANEOUS CORONARY INTERVENTION: A SECONDARY-ANALYSIS OF THE PACIFY RANDOMIZED CLINICAL TRIAL

Platelet function was measured at 2 hours using VerifyNow (Platelet Reactivity Units, PRU) and light-transmission aggregometry (measuring ADP-induced platelet aggregation). The lower dose fentanyl group also appeared to have more pronounced platelet inhibition by PRUs, though these results were not...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2018-03, Vol.71 (11), p.A1362-A1362
Main Authors: McEvoy, John W., Goli, Rakesh R., Ibrahim, Khalil, Shah, Rohan, Kickler, Thomas S., Clarke, William A., Schulman, Steven
Format: Article
Language:English
Subjects:
Angioplasty
Clinical trials
Fentanyl
Intravenous administration
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Summary:Platelet function was measured at 2 hours using VerifyNow (Platelet Reactivity Units, PRU) and light-transmission aggregometry (measuring ADP-induced platelet aggregation). The lower dose fentanyl group also appeared to have more pronounced platelet inhibition by PRUs, though these results were not significant (84 vs 119, p=0.11) In linear regression analyses, for every unit increase in procedural fentanyl dose, there was a 33 unit increase in PRU (p=0.03) and a 11% increase in ADP-induced platelet aggregation (p=0.01).
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(18)31903-X