THE WARBURG EFFECT IN THE HEART: INCREASED GLUCOSE METABOLISM DRIVES CARDIOMYOCYTE HYPERTROPHY IN RESPONSE TO ADRENERGIC STIMULATION

DNA, RNA, proteins, polar and aqueous fractions were separated, extracted and radioactivity (DPM) of each fraction was determined Results Treatment with ISO resulted in AVMC hypertrophy when glucose was present in the medium. [...]the lack of 14C enrichment of macromolecules in ISO treated AVCMs pro...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2018-03, Vol.71 (11), p.A802-A802
Main Authors: Davogustto, Giovanni, Dillon, William, Salazar, Rebecca, Vasquez, Hernan, Taegtmeyer, Heinrich
Format: Article
Language:English
Subjects:
Cardiology
Cardiomyocytes
Glucose metabolism
Heart
Hypertrophy
Metabolism
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Summary:DNA, RNA, proteins, polar and aqueous fractions were separated, extracted and radioactivity (DPM) of each fraction was determined Results Treatment with ISO resulted in AVMC hypertrophy when glucose was present in the medium. [...]the lack of 14C enrichment of macromolecules in ISO treated AVCMs provides evidence that in cardiomyocytes, the Warburg effect plays a different role than providing biosynthetic precursors and rather provides necessary chemical energy or reducing equivalents required for hypertrophy.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(18)31343-3