Production of Proteinase with Plasmin-Like and Prekallikrein Activating Activity by the Micromycete Aspergillus terreus

The effect of nitrogen sources in the fermentation medium and the cultivation conditions on the production of proteinases with plasmin-like and prekallikrein activation activity by micromycete Aspergillus terreus 2 was investigated. The highest secretion of proteinases was achieved when the micromyc...

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Bibliographic Details
Published in:Applied biochemistry and microbiology 2018-03, Vol.54 (2), p.206-210
Main Authors: Zvonareva, E. S., Osmolovskiy, A. A., Kreier, V. G., Baranova, N. A., Kotova, I. B., Egorov, N. S.
Format: Article
Language:English
Subjects:
Aspergillus terreus
Biochemistry
Biomedical and Life Sciences
Cultivation
Fermentation
Fibrin
Fibrinogen
Life Sciences
Medical Microbiology
Microbiology
Nitrogen sources
Plasmin
Proteinase
Secretion
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Summary:The effect of nitrogen sources in the fermentation medium and the cultivation conditions on the production of proteinases with plasmin-like and prekallikrein activation activity by micromycete Aspergillus terreus 2 was investigated. The highest secretion of proteinases was achieved when the micromycete was cultivated on a medium containing both amine- and mineral nitrogen sources at an initial pH of 5.5 and at 28°С. It was established that the extracellular micromycete proteinases are equally capable of hydrolyzing fibrin and fibrinogen.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683818020151