Oral exposure of deltamethrin and/or lipopolysaccharide (LPS) induced activation of the pulmonary immune system in Swiss albino mice

• Published in: Environmental science and pollution research international 2018-06, Vol.25 (16), p.15436-15448
• Main Authors: Tewari, Anita, Bedi, Jasbir, Singh, Baljit, Gill, Jatinder Paul Singh
• Format: Article
• Language: English
• Subjects: Acute toxicity; Albinism; Alveoli; Animals; Antigens; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Bacteria; Bronchus; Cell lineage; Chronic exposure; Cytokines; Damage assessment; Deltamethrin; Dose-Response Relationship, Drug; Earth and Environmental Science; Ecotoxicology; Endotoxins; Environment; Environmental Chemistry; Environmental Health; Environmental science; Exposure; Gram-negative bacteria; Immune system; Immune System - drug effects; Immune System - immunology; Immunization; Infiltration; Inflammation; Inflammation - chemically induced; Inflammatory response; Insecticides - toxicity; Leukocytes; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Low level; Lung - drug effects; Lung - immunology; Lungs; Lymphocytosis; Macrophages; Male; Metastases; Mice; Microorganisms; Neutropenia; Nitriles - toxicity; Proteins; Pyrethrins - toxicity; Pyrethroids; Research Article; Rodents; Septum; Thickening; TLR4 protein; Toll-like receptors; Toxicity; Tumor necrosis factor-α; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-018-1702-2

The deltamethrin, a synthetic pyrethroid, is used worldwide and has been linked with several type of acute toxicity. However, effect of low level of deltamethrin alone or in combination with the microbial antigen on pulmonary system is not understood. Lipopolysaccharide (LPS) was used as antigen which is a key inflammatory component of gram-negative bacteria, which induces a distinctive pattern of cytokine release that regulates inflammation. The aim was to determine whether chronic exposure to a low level of deltamethrin alone or in combination with LPS impair the lung response in adult male Swiss albino mice. The mice were orally exposed to different doses of deltamethrin (0.1, 0.05, 0.005, 0.001 mg/kg bwt) and then immunized with LPS at the 60th day. None of the treatment groups contained residues of deltamethrin above the limits of quantification. Deltamethrin combined with LPS challenge caused significant lymphocytosis and neutropenia in group 1 (0.1 mg/kg) mice ( P