Limitation of the Vitros dry-slide technique in measuring high concentrations of salicylate in plasma

The linearity of the Vitros dry-slide method for plasma salicylate was assessed in two ways: serial concentrations of sodium salicylate were added to fresh lithium heparin plasma, and the salicylate was determined both neat and in dilution. Vitros salicylate results submitted to the Heathcontrol Ext...

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Bibliographic Details
Published in:Annals of clinical biochemistry 2001-11, Vol.38 (Pt 6), p.711-713
Main Authors: IVERSEN, S. A, WALKER, A, AVADES, T. Y, WILSON, J. F
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Chemical Analysis - instrumentation
Blood Chemical Analysis - methods
Blood Chemical Analysis - standards
Blood Chemical Analysis - statistics & numerical data
Drug Overdose - blood
Drug Overdose - diagnosis
False Negative Reactions
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Miscellaneous. Technology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Quality Control
Reference Standards
Salicylic Acid - blood
Salicylic Acid - poisoning
Salicylic Acid - standards
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Summary:The linearity of the Vitros dry-slide method for plasma salicylate was assessed in two ways: serial concentrations of sodium salicylate were added to fresh lithium heparin plasma, and the salicylate was determined both neat and in dilution. Vitros salicylate results submitted to the Heathcontrol External Quality Assessment Scheme were compared to the spike value. Similar loss of linearity was observed in both cases. Serious salicylate overdosage requiring specific clinical treatment may have been underestimated.
ISSN:0004-5632
1758-1001
DOI:10.1258/0004563011900948