Updating the research on the chemopreventive and therapeutic role of the peptide lunasin

Chronic diseases have become the medical challenge of the 21st century because of their high incidence and mortality rates. Modulation of diet and lifestyle habits is considered as the best strategy for the prevention of these disorders. Health promoting benefits beyond their nutritional effects hav...

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2018-04, Vol.98 (6), p.2070-2079
Main Authors: Hsieh, Chia‐Chien, Martínez‐Villaluenga, Cristina, de Lumen, Ben O, Hernández‐Ledesma, Blanca
Format: Article
Language:English
Subjects:
Animals
bioactive peptide
Bioavailability
Cancer
chemopreventive and therapeutic properties
Cholesterol
Chronic Disease - drug therapy
Chronic Disease - prevention & control
chronic diseases
Chronic illnesses
Diet
Disorders
Food
Humans
Immunology
lunasin
Molecular modelling
Neoplasms - drug therapy
Neoplasms - prevention & control
Oxidative stress
Peptides
Peptides - therapeutic use
Preventive Medicine
Soybean Proteins - therapeutic use
Soybeans
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Summary:Chronic diseases have become the medical challenge of the 21st century because of their high incidence and mortality rates. Modulation of diet and lifestyle habits is considered as the best strategy for the prevention of these disorders. Health promoting benefits beyond their nutritional effects have been described for multiple dietary compounds. Among these compounds, the peptide lunasin is considered as one of the most promising. Naturally present in soybean, lunasin has been extensively studied in the last two decades because of its potential against chronic diseases such as cancer, cardiovascular and immunological disorders. The purpose of this article is to summarise the evidence on the presence of lunasin in soybean and derived foods, and its bioavailability once it is orally ingested. The protective and therapeutic effects of this peptide against cancer, oxidative stress, inflammation, and high cholesterol levels as well as the molecular mechanisms of action involved in these effects are also described in this review. © 2017 Society of Chemical Industry
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.8719