Re-Examination of the Esophageal Squamous Cell Carcinoma Model in Rats Induced by N-Nitrososarcosine Ethyl Ester Precursors

Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material....

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-03, Vol.164 (5), p.676-679
Main Authors: Shubin, A. V., Lesovaya, E. A., Kirsanov, K. I., Antoshina, E. E., Trukhanova, L. S., Gorkova, T. G., Belitsky, G. A., Yakubovskaya, M. G., Demidyuk, I. V.
Format: Article
Language:English
Subjects:
Animal models
Animals
Biomedical and Life Sciences
Biomedicine
Carcinoma, Squamous Cell - chemically induced
Carcinoma, Squamous Cell - pathology
Cell Biology
Esophageal cancer
Esophageal Neoplasms - chemically induced
Esophageal Neoplasms - pathology
Esophageal Squamous Cell Carcinoma
Esophagus
Health risk assessment
Internal Medicine
Laboratory animals
Laboratory Medicine
Male
Molecular modelling
Nitrosamines - toxicity
Pathology
Rats
Rats, Wistar
Squamous cell carcinoma
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Summary:Studies of the molecular mechanisms of esophageal cancer development have to be carried out on sufficient amount of tumor material, obtained under conditions of controlled exposure to carcinogenic factors. Esophageal cancer models on laboratory animals serve an indispensable source of this material. One of these models is esophageal cancer induction in rats by N-nitroso compound precursors. Despite adequate reproduction of human esophageal cancer, this model in fact has not been used since the 1990ies. Re-examination of esophageal cancer model, induced by N-nitrososarcosine ethyl ester precursors, is carried out and its efficiency in induction of squamous cell carcinoma is confirmed.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-018-4057-2