Au(III) complexes loaded pH‐responsive magnetic nanogels for cancer therapy

A novel pH‐responsive magnetic nanogels were developed with the aim of targeted delivering and simultaneously releasing of newly synthesized Au(III)‐based anticancer drug, Au(1,7‐Phen)Br3. The obtained nanogels were characterized by FT‐IR, DLS, EDAX, TEM, XRD, ICP‐Ms and MRI. The TEM images showed t...

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Bibliographic Details
Published in:Applied organometallic chemistry 2018-04, Vol.32 (4), p.n/a
Main Authors: Rezaei, Seyed Jamal Tabatabaei, Norouzi, Khadijeh, Hesami, Ali, Malekzadeh, Asemeh Mashhadi, Ramazani, Ali, Amani, Vahid, Ahmadi, Roya
Format: Article
Language:English
Subjects:
Au(III) complex
Cancer
Chemistry
Controlled release
Cytotoxicity
Fluorescence
magnetic nanogels
Magnetic resonance imaging
pH‐responsive
targeted drug delivery
Toxicity
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Summary:A novel pH‐responsive magnetic nanogels were developed with the aim of targeted delivering and simultaneously releasing of newly synthesized Au(III)‐based anticancer drug, Au(1,7‐Phen)Br3. The obtained nanogels were characterized by FT‐IR, DLS, EDAX, TEM, XRD, ICP‐Ms and MRI. The TEM images showed that the nanogels had a spherical shape with a mean diameter of 20 nm. The in vitro release studies of Au (III)‐loaded nanogels showed a pH‐triggered controlled release of drugs. The in vitro cytotoxicity assay of samples to human cervical cancer HeLa cell lines indicated that the Au(III)‐loaded magnetic nanogels exert higher cytotoxicity in comparison with free Au(III) complex. Fluorescent microscope images indicated that these magnetic nanogels possessed notable cell specific targeting in vitro in the presence of an external magnetic field. The results show that this superparamagnetic nanocarrier is a promising candidate for inhibiting growth of tumor cells. A novel multifunctional magnetically‐targeted gold(III) delivery system have been utilized as highly efficient targeted drug delivery nanocarriers.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.4303