Au(III) complexes loaded pH‐responsive magnetic nanogels for cancer therapy

• Published in: Applied organometallic chemistry 2018-04, Vol.32 (4), p.n/a
• Main Authors: Rezaei, Seyed Jamal Tabatabaei, Norouzi, Khadijeh, Hesami, Ali, Malekzadeh, Asemeh Mashhadi, Ramazani, Ali, Amani, Vahid, Ahmadi, Roya
• Format: Article
• Language: English
• Subjects: Au(III) complex; Cancer; Chemistry; Controlled release; Cytotoxicity; Fluorescence; magnetic nanogels; Magnetic resonance imaging; pH‐responsive; targeted drug delivery; Toxicity
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.4303

A novel pH‐responsive magnetic nanogels were developed with the aim of targeted delivering and simultaneously releasing of newly synthesized Au(III)‐based anticancer drug, Au(1,7‐Phen)Br3. The obtained nanogels were characterized by FT‐IR, DLS, EDAX, TEM, XRD, ICP‐Ms and MRI. The TEM images showed that the nanogels had a spherical shape with a mean diameter of 20 nm. The in vitro release studies of Au (III)‐loaded nanogels showed a pH‐triggered controlled release of drugs. The in vitro cytotoxicity assay of samples to human cervical cancer HeLa cell lines indicated that the Au(III)‐loaded magnetic nanogels exert higher cytotoxicity in comparison with free Au(III) complex. Fluorescent microscope images indicated that these magnetic nanogels possessed notable cell specific targeting in vitro in the presence of an external magnetic field. The results show that this superparamagnetic nanocarrier is a promising candidate for inhibiting growth of tumor cells. A novel multifunctional magnetically‐targeted gold(III) delivery system have been utilized as highly efficient targeted drug delivery nanocarriers.