Analysis of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene K121Q Polymorphism Association with Some Risk Factors of Atherosclerosis in Patients with Acute Coronary Syndrome

The present study was performed to investigate whether common single-nucleotide polymorphism K121Q (rs1044498) of the ENPP1 gene is associated with the known risk factors of atherosclerosis (overweight, dyslipoproteinemia, hypertension, diabetes, smoking, and hypercoagulability) in persons with acut...

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Bibliographic Details
Published in:Cytology and genetics 2018-03, Vol.52 (2), p.127-131
Main Authors: Ataman, A. V., Harbuzova, V. Yu, Obukhova, O. A., Dubovyk, Ye. I.
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Alleles
Arteriosclerosis
Atherosclerosis
Biomedical and Life Sciences
Biomedicine
Body weight
Cholesterol
Diabetes mellitus
Fibrin
Fibrinolysis
Gene polymorphism
Genotypes
Homozygotes
Human Genetics
Low density lipoprotein
Overweight
Phosphodiesterase
Pyrophosphatase
Restriction fragment length polymorphism
Risk factors
Single-nucleotide polymorphism
Smoking
Statistical analysis
Citations: Items that this one cites
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Summary:The present study was performed to investigate whether common single-nucleotide polymorphism K121Q (rs1044498) of the ENPP1 gene is associated with the known risk factors of atherosclerosis (overweight, dyslipoproteinemia, hypertension, diabetes, smoking, and hypercoagulability) in persons with acute coronary syndrome. Venous blood of 118 patients was genotyped for the polymorphism by PCR and restriction fragment length polymorphism method. In patients divided into two subgroups according to their genotype (KK and KQ + QQ), the statistically significant differences were revealed only for plasma LDL-cholesterol level and fibrinolytic activity. The carriers of minor allele (KQ + QQ) had lower LDL-cholesterol concentration and the time of fibrinolysis than the major allele homozygotes (KK). The division of patients into subgroups according to presence or absence of some risk factors for atherosclerosis showed no statistically significant differences between K121Q genotype distributions for any of the comparison.
ISSN:0095-4527
1934-9440
DOI:10.3103/S0095452718020020