Copper‐catalyzed Intramolecular Carbotrifluoromethylation of Ene‐Imines for the Construction of 3‐(2,2,2‐Trifluoro)ethylated 4‐Amino‐Chromans

A mild and efficient copper‐catalyzed intramolecular carbotrifluoromethylation of ene‐imines with Togni reagent as a trifluoromethylating reagent was realized. The reaction tolerates a range of substrates to give the corresponding 3‐trifluoroethylated 4‐amino‐chromans in moderate to good yields. A p...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2018-04, Vol.360 (7), p.1402-1406
Main Authors: Ye, Qin, Jiang, Min, Deng, Qing‐Hai, Liu, Jin‐Tao
Format: Article
Language:English
Subjects:
4-amino-chroman
Copper
ene-imine
Imines
Reagents
Substrates
Togni reagent
trifluoromethylation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A mild and efficient copper‐catalyzed intramolecular carbotrifluoromethylation of ene‐imines with Togni reagent as a trifluoromethylating reagent was realized. The reaction tolerates a range of substrates to give the corresponding 3‐trifluoroethylated 4‐amino‐chromans in moderate to good yields. A possible mechanism was proposed based on the experimental results.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201701298