One-pot synthesis of five substituted tetrahydropyridines using nano-Al2O3/BF3/Fe3O4 as a highly efficient nano-catalyst

Nano-Al 2 O 3 /BF 3 /Fe 3 O 4 was synthesized as an efficient and reusable catalyst. The synthesized magnetic catalyst has been characterized by various methods such as FT-IR, FESEM, TGA, TEM, VSM, XRF, XRD and BET. This catalyst does not need special precautions for preparation, handling or storage...

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Bibliographic Details
Published in:Research on chemical intermediates 2018-05, Vol.44 (5), p.3493-3505
Main Authors: Babaei, Elaheh, Mirjalili, Bi Bi Fatemeh
Format: Article
Language:English
Subjects:
Aldehydes
Aluminum oxide
Ambient temperature
Catalysis
Catalysts
Catalytic activity
Chemical synthesis
Chemistry
Chemistry and Materials Science
Esters
Fourier transforms
Inorganic Chemistry
Iron oxides
NMR
Nuclear magnetic resonance
Nuclear reactions
Physical Chemistry
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Summary:Nano-Al 2 O 3 /BF 3 /Fe 3 O 4 was synthesized as an efficient and reusable catalyst. The synthesized magnetic catalyst has been characterized by various methods such as FT-IR, FESEM, TGA, TEM, VSM, XRF, XRD and BET. This catalyst does not need special precautions for preparation, handling or storage, and it can be stored at an ambient temperature for months without losing its catalytic activity. Five-substituted tetrahydropyridines and their derivatives have an interesting class of pharmaceutical activities. Thus, the nano-Al 2 O 3 /BF 3 /Fe 3 O 4 catalyst was used to prepare five-substituted tetrahydropyridines by one-pot multicomponent reactions of aromatic aldehydes, anilines and β-keto-esters under solvent free conditions. The structure of products were studied by Fourier transform spectroscopy and nuclear magnetic resonance. The present protocol has notable advantages of easy purification, clean and convenient procedure and high yields for isolated products. In addition, this catalyst could be recycled several times without reduction in its admirable activity. Graphical Abstract
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-018-3320-5