Effect of a single dose vitamin D3 on postprandial arterial stiffness and inflammation in vitamin D deficient women

• Published in: The journal of clinical endocrinology and metabolism 2017-03, Vol.102 (3), p.992-1000
• Main Authors: de Vries, Marijke A, van der Meulen, Noëlle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, Castro Cabezas, Manuel
• Format: Article
• Language: English
• Subjects: Activation; Adult; Apolipoprotein A-I - metabolism; Apolipoproteins B - metabolism; Area Under Curve; Body weight; C-Reactive Protein - immunology; CD11b antigen; Cell activation; Cholecalciferol - administration & dosage; Cholesterol, HDL - metabolism; Cholesterol, LDL - metabolism; Complement C3 - immunology; Complement component C3; Diabetes mellitus; Dietary supplements; Double-Blind Method; Fasting; Female; Humans; Inflammation; Leukocyte Count; Monocytes; Monocytes - immunology; Neutrophils - immunology; Obesity - complications; Obesity - metabolism; Obesity - physiopathology; Overweight; Overweight - complications; Overweight - metabolism; Overweight - physiopathology; Postprandial Period; Pulse Wave Analysis; Triglycerides - metabolism; Vascular Stiffness; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - metabolism; Vitamin D Deficiency - complications; Vitamin D Deficiency - drug therapy; Vitamin D Deficiency - metabolism; Vitamin D Deficiency - physiopathology; Vitamin D3; Vitamins - administration & dosage; Wave velocity; Young Adult
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2016-3394

Context:Cholecalciferol (vitamin D3) may improve vascular function and reduce inflammation, potentially providing an explanation for the proposed cardiovascular protection by vitamin D .Objective:We investigated whether cholecalciferol supplementation reduces postprandial arterial dysfunction and inflammation.Design:This was a randomized 1:1, double blind trial.Setting:The study was conducted in the Diabetes and Vascular Center of the Franciscus Gasthuis, Rotterdam, The Netherlands.Patients:Twenty-four healthy premenopausal, overweight or obese, vitamin D deficient women.Interventions:A single high (300 000 IU) or low dose (75 000 IU) cholecalciferol.Main outcome measures:The effect of low and high dose cholecalciferol on postprandial leukocyte activation markers, pulse wave velocity (PWV) and augmentation index (AIx) during an oral fat loading test, expressed as area under the curve (AUC).Results:High and low dose supplementation increased vitamin D by 163±134%, p