Development of antimicrobial‐loaded polyurethane films for drug‐eluting catheters

ABSTRACT To prepare antibacterial, polymeric catheters for preventing catheter‐induced infections, sulfathiazole was loaded into polyurethane by solubilizing with solvents and the resultant films were cast. Fourier transform infrared spectroscopy confirmed the presence of sulfathiazole in the drug‐l...

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Bibliographic Details
Published in:Journal of applied polymer science 2018-07, Vol.135 (27), p.n/a
Main Authors: Barde, Mehul, Davis, Montoia, Rangari, Shivani, Mendis, Hajeewaka C., De La Fuente, Leonardo, Auad, Maria L.
Format: Article
Language:English
Subjects:
Antibacterial materials
biomedical applications
Catheters
Computing time
Deionization
Drug delivery systems
Dynamic mechanical analysis
E coli
Fourier transforms
Materials science
Mathematical models
Mechanical properties
Polymers
polyurethane
Polyurethane resins
Thermal analysis
Thermodynamic properties
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Summary:ABSTRACT To prepare antibacterial, polymeric catheters for preventing catheter‐induced infections, sulfathiazole was loaded into polyurethane by solubilizing with solvents and the resultant films were cast. Fourier transform infrared spectroscopy confirmed the presence of sulfathiazole in the drug‐loaded polyurethane films. The thermal and mechanical properties of the films were assessed using differential scanning calorimetry and dynamic mechanical analysis. The drug‐loaded films were immersed in constantly stirred, deionized water at 37 °C for in vitro drug release study. The experimental data obtained from the in vitro drug release study were fit into mathematical models. Antibacterial efficiency of released sulfathiazole was evaluated by Escherichia coli growth inhibition test. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46467.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.46467