Head and voice tremor improving with immunotherapy in an anti‐ NF 155 positive CIDP patient

Chronic inflammatory demyelinating polyradiculoneuropathy with NF 155 antibodies (anti‐ NF 155+) constitutes a specific chronic inflammatory demyelinating polyradiculoneuropathy subset with a high incidence of limb's tremor and poor response to conventional therapies. We report a patient with c...

Full description

Saved in:
Bibliographic Details
Published in:Annals of clinical and translational neurology 2018-04, Vol.5 (4), p.499-501
Main Authors: Painous, Cèlia, López‐Pérez, Mª Ángeles, Illa, Isabel, Querol, Luis
Format: Article
Language:English
Subjects:
Ataxia
Immunoglobulins
Immunotherapy
Monoclonal antibodies
Patients
Tremor (Muscular contraction)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic inflammatory demyelinating polyradiculoneuropathy with NF 155 antibodies (anti‐ NF 155+) constitutes a specific chronic inflammatory demyelinating polyradiculoneuropathy subset with a high incidence of limb's tremor and poor response to conventional therapies. We report a patient with chronic inflammatory demyelinating polyradiculoneuropathy anti‐ NF 155+ with a severe tremor involving limbs, head and voice that responded very well to rituximab. This response correlated with a sharp decrease in the anti‐ NF 155 titers. This case is the first report associating head and voice tremor to chronic inflammatory demyelinating polyradiculoneuropathy, reinforces the hypothesis of the cerebellar origin of this tremor and provides indirect evidence that the antibodies may be the cause of the tremor in these patients.
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.539