Yttrium-90 ibritumomab tiuxetan (Zevalin) followed by BEAM (Z-BEAM) conditioning regimen and autologous stem cell transplantation (ASCT) in relapsed or refractory high-risk B-cell non-Hodgkin lymphoma (NHL): a single institution Italian experience

Chemo-refractory NHL has a very poor outcome; the addiction of RIT to salvage regiment pre ASCT had recently demonstrated promising results.We performed a retrospective sequential study to determine the feasibility of standard Zevalin with BEAM in high-risk relapse/refractory NHL . A matched cohort...

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Bibliographic Details
Published in:Annals of hematology 2018-09, Vol.97 (9), p.1619-1626
Main Authors: Ciochetto, Chiara, Botto, Barbara, Passera, Roberto, Bellò, Marilena, Benevolo, Giulia, Boccomini, Carola, Castellino, Alessia, Chiappella, Annalisa, Freilone, Roberto, Nicolosi, Maura, Orsucci, Lorella, Pecoraro, Clara, Pregno, Patrizia, Bisi, Gianni, Vitolo, Umberto
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Monoclonal - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carmustine - therapeutic use
Combined Modality Therapy
Cytarabine - therapeutic use
Drug Resistance, Neoplasm - drug effects
Female
Hematology
Hematopoietic Stem Cell Transplantation
Humans
Immunotherapy
Italy - epidemiology
Lymphoma
Lymphoma, B-Cell - drug therapy
Lymphoma, B-Cell - epidemiology
Lymphoma, B-Cell - pathology
Lymphoma, B-Cell - therapy
Lymphoma, Non-Hodgkin - drug therapy
Lymphoma, Non-Hodgkin - epidemiology
Lymphoma, Non-Hodgkin - pathology
Lymphoma, Non-Hodgkin - therapy
Male
Medicine
Medicine & Public Health
Melphalan - therapeutic use
Middle Aged
Monoclonal antibodies
Neoplasm Invasiveness
Oncology
Original Article
Podophyllotoxin - therapeutic use
Recurrence
Retrospective Studies
Salvage Therapy - methods
Stem cell transplantation
Targeted cancer therapy
Transplantation Conditioning - methods
Transplantation, Autologous
Treatment Outcome
Young Adult
Yttrium Radioisotopes - administration & dosage
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Summary:Chemo-refractory NHL has a very poor outcome; the addiction of RIT to salvage regiment pre ASCT had recently demonstrated promising results.We performed a retrospective sequential study to determine the feasibility of standard Zevalin with BEAM in high-risk relapse/refractory NHL . A matched cohort analysis with a group treated with standard BEAM without Zevalin was performed as secondary endpoint. Between October 2006 and January 2013, 37 NHL patients at high risk for progression or early (
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-018-3328-3