Visible Light‐Induced Aerobic Oxidation of Indoles: One‐Pot Formation of 4‐Quinolones at Room Temperature

A one‐pot synthesis of 4‐quinolones starting from indoles is disclosed. This cascade reaction involves a photocatalytic aerobic oxidation of indoles using visible light and a subsequent base‐promoted Camps cyclization. The advantages of the present protocol include the use of environmentally benign...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2018-04, Vol.7 (4), p.711-714
Main Authors: Ji, Xiaochen, Li, Dongdong, Wang, Zhongzhen, Tan, Muyun, Huang, Huawen, Deng, Guo‐Jun
Format: Article
Language:English
Subjects:
Cascade chemical reactions
Chemical synthesis
Indoles
Organic chemistry
Oxidation
photocatalysis
quinolones
Room temperature
synthetic methods
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Summary:A one‐pot synthesis of 4‐quinolones starting from indoles is disclosed. This cascade reaction involves a photocatalytic aerobic oxidation of indoles using visible light and a subsequent base‐promoted Camps cyclization. The advantages of the present protocol include the use of environmentally benign and inexpensive oxygen as the sole oxidant, easy handling at room temperature, as well as step‐ and atom‐economy. I have a blue house with a blue LED: A facile and mild synthesis of 4‐quinolones through ring‐expansion reaction of indoles with aerobic visible light photocatalysis is described.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.201800036