Investigation of Chemical Properties and Antimicrobial Activity of Acetylene Glycidyl Ethers

Reactions of acetylene glycidyl ethers with butylamine and ethylene diamine lead to the oxirane ring opening according to the Krasusky rule with the formation of acetylene aminoalcohols. In reaction with thiourea the oxygen atom in the ring is replaced by sulfur leading to the corresponding thiirane...

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Bibliographic Details
Published in:Russian journal of general chemistry 2018-03, Vol.88 (3), p.389-392
Main Authors: Movsumzade, M. M., Shatirova, M. I., Dzhafarova, U. Sh, Niyazova, N. K.
Format: Article
Language:English
Subjects:
Acetylene
Antiinfectives and antibacterials
Antimicrobial agents
Chemical properties
Chemical reactions
Chemical tests and reagents
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Ethers
Ethylene oxide
Ethylenediamines
Heterocyclic compounds
Ring opening
Sulfur compounds
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Summary:Reactions of acetylene glycidyl ethers with butylamine and ethylene diamine lead to the oxirane ring opening according to the Krasusky rule with the formation of acetylene aminoalcohols. In reaction with thiourea the oxygen atom in the ring is replaced by sulfur leading to the corresponding thiiranes in a high yield. The synthesized compounds possess high antimicrobial activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363218030027