Rosmarinic acid: modes of action, medicinal values and health benefits

The supplementation of livestock rations with herbs containing bioactive components, such as rosmarinic acid (RA), have shown promising results as a natural feed additive in promoting growth, productive and reproductive performance, feed utilization, fertility, anti-oxidant status and immunologic in...

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Bibliographic Details
Published in:Animal health research reviews 2017-12, Vol.18 (2), p.167-176
Main Authors: Alagawany, Mahmoud, Abd El-Hack, Mohamed Ezzat, Farag, Mayada Ragab, Gopi, Marappan, Karthik, Kumaragurubaran, Malik, Yashpal Singh, Dhama, Kuldeep
Format: Article
Language:English
Subjects:
Amino acids
Animal diseases
Animal health
Animal nutrition
Animals
Antiinfectives and antibacterials
Antioxidants
Apoptosis
Cinnamates - pharmacology
Cinnamates - therapeutic use
Depsides - pharmacology
Depsides - therapeutic use
Diabetes mellitus
Feed additives
Feed conversion
Fertility
Flavor
Herbs
Humans
Immunomodulation
Inflammation
Lamiaceae
Livestock
Meat
Meat products
Metabolism
Metabolites
Microorganisms
Nanoparticles
Nutrition
Oxidizing agents
Poultry
Reactive oxygen species
Reagents
Reproduction
Rodents
Rosmarinic Acid
Shelf life
Side effects
Skin
Treatment Outcome
Urine
Veterinary medicine
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Summary:The supplementation of livestock rations with herbs containing bioactive components, such as rosmarinic acid (RA), have shown promising results as a natural feed additive in promoting growth, productive and reproductive performance, feed utilization, fertility, anti-oxidant status and immunologic indices. Furthermore, RA reportedly reduces the risks of various animal diseases and mitigates side effects of chemical and synthetic drugs. RA is a natural polyphenol present in several Lamiaceae herbs like Perilla frutescens, and RA is becoming an integral component of animal nutrition as it counters the effect of reactive oxygen species induced in the body as a consequence of different kinds of stressors. Studies have further ascertained the capability of RA to work as an anti-microbial, immunomodulatory, anti-diabetic, anti-allergic, anti-inflammatory, hepato- and renal-protectant agent, as well as to have beneficial effects during skin afflictions. Additionally, RA is favored in meat industries due to enhancing the quality of meat products by reportedly improving shelf-life and imparting desirable flavor. This review describes the beneficial applications and recent findings with RA, including its natural sources, modes of action and various useful applications in safeguarding livestock health as well as important aspects of human health.
ISSN:1466-2523
1475-2654
DOI:10.1017/S1466252317000081