388 OXIDATIVE STRESS IN OVERWEIGHT CHILDREN AND ADOLESCENTS

• Published in: Journal of investigative medicine 2007-01, Vol.55 (1), p.S139
• Main Authors: Evans, W. N., Mayman, G. A., Acherman, R. J., Cass, K. A., Luna, C. F., Collazos, A. J.C., Restrepo, H.
• Format: Article
• Language: English
• Subjects: Body mass index; Obesity; Oxidation; Oxidative stress; Teenagers
• ISSN: 1081-5589; 1708-8267

BackgroundIn adult studies, elevated concentrations of oxidative stress markers have been associated with obesity and other risk factors for cardiovascular disease.ObjectiveTo compare concentrations of urinary oxidative stress markers between overweight and normal-weight children and adolescents.Methods and PatientsThis pilot study compared data from 23 children and adolescents with a body mass index (BMI) ≥ 95th percentile, in good health conditions except for their obesity, with a group of 17 normal BMI percentile peers. Oxidative stress test, which includes 8-epi-PGF2£ and 8-epi-PGF2£/creatinine ratio, were measured in a spot urine morning sample. Spearman correlation and nonparametric tests were used for statistical analysis.ResultsThe group of overweight children was composed of 14 boys and 9 females, with a mean age of 12.3 ± 2.0 years and a mean BMI Z-score of 2.1 ± 0.4; the group of normal-weight children had 12 boys and 5 girls, with a mean age of 13.7 ± 2.2 and a mean BMI Z-score of −0.5 ± 1.3. There was no significant difference between groups in 8-epi-PG F2£ (2,561.8 ± 1,578.2 vs 2,601.5 ± 1,337.2 pg/mL, p = .7) or 8-epi-PGF2£/creatinine ratio (17.2 ± 5.2 vs 17.9 ± 5.9, p = .8). 8-epi-PG F2£ was not correlated with BMI or BMI Z-score.ConclusionIn this group of overweight children and adolescents, oxidative stress markers were not significantly elevated or correlated with BMI.