Miconazole enhances nerve regeneration and functional recovery after sciatic nerve crush injury

ABSTRACT Introduction: Improving axonal outgrowth and remyelination is crucial for peripheral nerve regeneration. Miconazole appears to enhance remyelination in the central nervous system. In this study we assess the effect of miconazole on axonal regeneration using a sciatic nerve crush injury mode...

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Bibliographic Details
Published in:Muscle & nerve 2018-05, Vol.57 (5), p.821-828
Main Authors: Lin, Tao, Qiu, Shuai, Yan, Liwei, Zhu, Shuang, Zheng, Canbin, Zhu, Qingtang, Liu, Xiaolin
Format: Article
Language:English
Subjects:
Antifungal agents
Cell proliferation
Central nervous system
Crushing
Injuries
Miconazole
Muscles
Myelination
Nerve conduction
nerve crush injury
nerve regeneration functional recovery
neurotrophin expression
rat model
Rats
Recovery
Recovery (Medical)
Recovery of function
Regeneration
Regrowth
Rodents
Schwann cells
Sciatic nerve
Sensory neurons
Western blotting
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Summary:ABSTRACT Introduction: Improving axonal outgrowth and remyelination is crucial for peripheral nerve regeneration. Miconazole appears to enhance remyelination in the central nervous system. In this study we assess the effect of miconazole on axonal regeneration using a sciatic nerve crush injury model in rats. Methods: Fifty Sprague‐Dawley rats were divided into control and miconazole groups. Nerve regeneration and myelination were determined using histological and electrophysiological assessment. Evaluation of sensory and motor recovery was performed using the pinprick assay and sciatic functional index. The Cell Counting Kit‐8 assay and Western blotting were used to assess the proliferation and neurotrophic expression of RSC 96 Schwann cells. Results: Miconazole promoted axonal regrowth, increased myelinated nerve fibers, improved sensory recovery and walking behavior, enhanced stimulated amplitude and nerve conduction velocity, and elevated proliferation and neurotrophic expression of RSC 96 Schwann cells. Discussion: Miconazole was beneficial for nerve regeneration and functional recovery after peripheral nerve injury. Muscle Nerve 57: 821–828, 2018
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.26033