Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Tröger's base-Ru(ii)-curcumin organometallic conjugate

The synthesis, photophysics and biological investigation of fluorescent 4-amino-1,8-naphthalimide Tröger's bases (TB-1-TB-3) and a new Tröger's base p-cymene-Ru(ii)-curcumin organometallic conjugate (TB-Ru-Cur) are described; these compounds showed fast cellular uptake and displayed good l...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (33), p.4120-4123
Main Authors: Shanmugaraju, Sankarasekaran, la Cour Poulsen, Bjørn, Arisa, Tobi, Umadevi, Deivasigamani, Dalton, Hannah L, Hawes, Chris S, Estalayo-Adrián, Sandra, Savyasachi, Aramballi J, Watson, Graeme W, Williams, D Clive, Gunnlaugsson, Thorfinnur
Format: Article
Language:English
Subjects:
Antiproliferatives
Fluorescence
Synthesis
Toxicity
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Summary:The synthesis, photophysics and biological investigation of fluorescent 4-amino-1,8-naphthalimide Tröger's bases (TB-1-TB-3) and a new Tröger's base p-cymene-Ru(ii)-curcumin organometallic conjugate (TB-Ru-Cur) are described; these compounds showed fast cellular uptake and displayed good luminescence and cytotoxicity against cervical cancer cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01584h