Case of thymoma‐associated cutaneous graft‐versus‐host disease‐like disease successfully improved by narrowband ultraviolet B phototherapy

Thymoma‐associated graft‐versus‐host disease (GVHD)‐like disease is a rare paraneoplastic disease seen in patients with thymoma. Here, we describe the first case of thymoma‐associated GVHD‐like disease localized to the skin that was successfully improved by a combination of systemic corticosteroids...

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Bibliographic Details
Published in:Journal of dermatology 2018-04, Vol.45 (4), p.479-482
Main Authors: Yatsuzuka, Kazuki, Tohyama, Mikiko, Oda, Fumiko, Hashimoto, Takashi, Sayama, Koji
Format: Article
Language:English
Subjects:
Corticosteroids
Foxp3
Foxp3 protein
Graft-versus-host reaction
graft‐versus‐host disease
Light therapy
Lymphocytes
narrowband ultraviolet B phototherapy
paraneoplastic disease
Phototherapy
Skin
Skin diseases
Thymoma
Toxic epidermal necrolysis
Ultraviolet radiation
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Summary:Thymoma‐associated graft‐versus‐host disease (GVHD)‐like disease is a rare paraneoplastic disease seen in patients with thymoma. Here, we describe the first case of thymoma‐associated GVHD‐like disease localized to the skin that was successfully improved by a combination of systemic corticosteroids and whole‐body narrowband ultraviolet (UV)‐B phototherapy. The patient had developed toxic epidermal necrolysis‐like erosive skin lesions over the whole body. Although systemic corticosteroids were effective up to a point, we were unable to begin the steroid taper. The addition of systemic narrowband UV‐B phototherapy improved the skin manifestation of this disease, allowing corticosteroids to be reduced to a third of the original dose. Histopathologically, it was confirmed that the proportion of Foxp3‐positive lymphocytes in the skin increased after narrowband UV‐B irradiation. We propose that whole‐body narrowband UV‐B phototherapy is a good therapeutic option for the skin manifestation of thymoma‐associated GVHD‐like disease.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.14176